Induction of Cell Cycle Arrest, Apoptosis, and Reducing the Expression of MCM Proteins in Human Lung Carcinoma A549 Cells by Cedrol, Isolated from<i>Juniperus chinensis</i>
Hee Jung Yun, Da Jeoung Jeoung, Soojung Jin, Jungha Park, Eun‐Woo Lee, Hyun–Tai Lee, Yung Hyun Choi, Byung Woo Kim, Hyun Ju Kwon
Abstract
, in reducing the expression of MCM proteins in human lung carcinoma A549 cells. Remarkably, cedrol also strongly inhibited the expression of all other MCM protein family members in A549 cells. Moreover, cedrol treatment reduced cell viability in A549 cells, accompanied by cell cycle arrest at the G1 phase, and enhanced apoptosis. Taken together, this study broadens our understanding of how cedrol executes its anticancer activity while demonstrating that cedrol has potential application in the treatment of human lung cancer as an inhibitor of MCM proteins.
Topics & Concepts
ApoptosisA549 cellCell cycle checkpointHuman lungCell cycleCell biologyCancer researchBiologyChemistryBotanyBiochemistryCell cultureGeneticsBiological Activity of Diterpenoids and BiflavonoidsTraditional Chinese Medicine AnalysisNatural product bioactivities and synthesis