DFT insight into asymmetric alkyl–alkyl bond formation <i>via</i> nickel-catalysed enantioconvergent reductive coupling of racemic electrophiles with olefins
Chaoshen Zhang, Beibei Zhang, Zhong Liang, Xiang‐Yu Chen, Zhixiang Wang
Abstract
The enantioconvergent alkyl–alkyl coupling involves two competitive catalytic cycles with nickel(0) and nickel( i ) active catalysts, respectively. K 3 PO 4 plays a crucial role to enable the hydride transfer from hydrosilane to nickel–bromine species.
Topics & Concepts
AlkylChemistryNickelElectrophileCatalysisHydrideBromineOrganic chemistryMedicinal chemistryMetalOrganoboron and organosilicon chemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization Methods