Carboxyl-Assisted <i>meta</i>-Selective C–H Functionalizations of Benzylsulfonamides
Lei Cai, Shangda Li, Chunlin Zhou, Gang Li
Abstract
A protocol of carboxyl-group-assisted, Pd(II)-catalyzed remote meta-C(sp2)–H olefination and arylation of benzylsulfonamides has been developed. It was supposed to proceed through a κ2 coordination of the carboxyl group to the Pd center. These findings demonstrated the versatility of carboxyl-assisted remote meta-C–H activation strategy and might stimulate the exploration of novel reactivity and selectivity of other traditional chelating groups in different contexts.
Topics & Concepts
ChemistryCombinatorial chemistryStereochemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques