Regioselective synthesis of isoquinolinonediones through remote unactivated C(sp<sup>3</sup>)–H bonds
Lei Huang, Jun Sun, Boxuan Sun, Shengjie Song, Jianjun Li
Abstract
a 1,5-hydrogen atom transfer (HAT) process, triggered by heteroatom-centred radicals generated directly under silver catalysis. A broad substrate scope and excellent regio-/chemo-selective control are demonstrated in this method.
Topics & Concepts
RegioselectivityChemistryStereochemistryCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalysisCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsOxidative Organic Chemistry Reactions