Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines
Mikhail Krasavin, Maria Adamchik, Andrey Bubyrev, Christopher Heim, Samuel Maiwald, Daniil Zhukovsky, Petr A. Zhmurov, Alexander S. Bunev, Marcus D. Hartmann
Topics & Concepts
CereblonChemistryStereochemistryThio-Ubiquitin ligaseBiochemistryUbiquitinGeneProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways