Design, synthesis, characterization, computational study and in-vitro antioxidant and anti-inflammatory activities of few novel 6-aryl substituted pyrimidine azo dyes
Aziz Unnisa, Amr S. Abouzied, Anupama Baratam, K. N. V. Chenchu Lakshmi, Talib Hussain, Rama Devi Kunduru, Humera Banu, Syeda Bushra Fatima, Arshad Hussian, Kesavanarayanan Krishnan Selvarajan
Abstract
A series of 6-aryl substituted pyrimidine azodyes were synthesized by coupling of phenyl pyrimidine 2-amine with different aromatic amines. The synthetic compounds were screened for their in-vitro antioxidant and anti-inflammatory activities. The characterization of the synthesized compounds was carried out by IR, 1H NMR, 13C NMR and Mass spectrophotometry. Computational study of designed compounds was done by OCHEM, Molinspiration cheminformatics, Datawarrior, and Swiss ADME. DPPH assay was used to determine the antioxidant activity and heat hemolysis method for anti-inflammatory activity.