AR-12 Exhibits Direct and Host-Targeted Antibacterial Activity toward <i>Mycobacterium abscessus</i>
Shaoyan Zhang, Yuzhen Zou, Qi Guo, Jianhui Chen, Liyun Xu, Xiaoyu Wan, Zhemin Zhang, Bing Li, Haiqing Chu
Abstract
Therapeutic options for Mycobacterium abscessus infections are extremely limited. New or repurposed drugs are needed. The anti- M. abscessus activity of AR-12 (OSU-03012), reported to express broad-spectrum antimicrobial effects, was investigated in vitro and in vivo . Antimicrobial susceptibility testing was performed on 194 clinical isolates. Minimum bactericidal concentration and time-kill kinetics assays were conducted to distinguish the bactericidal versus bacteriostatic activity of AR-12.
Topics & Concepts
Mycobacterium abscessusAntimicrobialMicrobiologyIn vivoIn vitroMycobacteriumMinimum inhibitory concentrationAntibacterial agentBiologyAntibioticsChemistryBacteriaBiochemistryBiotechnologyGeneticsMycobacterium research and diagnosisInfectious Diseases and MycologyTuberculosis Research and Epidemiology