Endogenous DEL-1 restrains melanoma lung metastasis by limiting myeloid cell–associated lung inflammation
Young‐Min Hyun, Sang‐Uk Seo, Woo Seon Choi, Hyung‐Joon Kwon, Dong‐Young Kim, Soi Jeong, Gyeong-Yi Kang, Eunbi Yi, Min-Jung Kim, Hyun Jin Ryu, Mark R. Looney, Eun Young Choi, Hun Sik Kim
Abstract
neutrophil accumulation in lung metastatic niche, leading to IL-17A up-regulation from γδ T cells and reduced antimetastatic NK cells. In support, neutrophil depletion or recombinant DEL-1 treatment profoundly reverses these effects. Thus, our results identify DEL-1 as a previously unrecognized link between tumor-induced inflammation and pulmonary metastasis.
Topics & Concepts
EndogenyLimitingLungInflammationMyeloidCancer researchMetastasisMedicineMelanomaImmunologyBiologyCancerInternal medicineMechanical engineeringEngineeringImmune cells in cancerPhagocytosis and Immune RegulationImmune Cell Function and Interaction