Palmarumycin P3 Reverses Mrr1-Mediated Azole Resistance by Blocking the Efflux Pump Mdr1
Minghui Song, Ming Zhang, Jinghui Lu, Fei Xie, Jintong Song, Xiaoyi Luan, Xuben Hou, Hong‐Xiang Lou, Wenqiang Chang
Abstract
Palmarumycin P3 (PP3) reduces fluconazole-induced MDR1 transcription to reverse azole resistance in clinical Candida strains. Here, we demonstrated that PP3 restores the susceptibility to several antifungal drugs for Candida albicans strains with gain-of-function mutations in the transcription factor Mrr1.
Topics & Concepts
EffluxCandida albicansAzoleFluconazoleCorpus albicansBiologyMicrobiologyTranscription factorChemistryGeneticsAntifungalGeneAntifungal resistance and susceptibilityAntibiotic Resistance in BacteriaFungal Infections and Studies