Using a high-throughput method in the micronucleus assay to compare animal-free with rat-derived S9
Julia Brendt, Carina Lackmann, Sebastian Heger, Mirna Velki, Sarah E. Crawford, Hongxia Xiao, Beat Thalmann, Andreas Schiwy, Henner Hollert
Topics & Concepts
Micronucleus testMicronucleusGenotoxicityComputational biologyToxicologyChinese hamsterBiologyIn vitro toxicologyS9 fractionBioassayIn vitroPharmacologyChemistryBiochemical engineeringBiochemistryToxicityGeneticsMicrosomeOrganic chemistryEngineeringCarcinogens and Genotoxicity AssessmentEffects and risks of endocrine disrupting chemicalsAnimal testing and alternatives