Organometallic chemistry and application of palladacycles in asymmetric hydrophosphination reactions
Jeffery Wee Kiong Seah, Ronald Hong Xiang Teo, Pak‐Hing Leung
Abstract
A number of palladacycles containing chiral chelating auxiliaries have been utilized as efficient catalysts for asymmetric hydrophosphination reactions. In all cases, the chiral auxiliaries remained coordinated to the palladium centres throughout the course of the reactions. Despite the presence of a large quantity of powerful tertiary phosphines, which are known to be strong metal ion sequesters, the expected catalyst poisoning was rarely observed in these palladacycle catalyzed processes. This review highlights the unique stereoelectronic features and the important organometallic chemistry of palladacycle catalysts which are essential to their synthetic operations.
Topics & Concepts
ChemistryCatalysisOrganometallic chemistryPalladiumChelationOrganic chemistryGroup 2 organometallic chemistryMetalCombinatorial chemistryMoleculeAsymmetric Hydrogenation and CatalysisOrganoboron and organosilicon chemistryCatalytic Cross-Coupling Reactions