A New Selective Pharmacological Enhancer of the Orai1 Ca<sup>2+</sup> Channel Reveals Roles for Orai1 in Smooth and Skeletal Muscle Functions
Iman Azimi, Ralph J. Stevenson, Xuexin Zhang, Aldo Meizoso‐Huesca, Ping Xin, Martin Johnson, Jack U. Flanagan, Silke B. Chalmers, Ryan E. Yoast, Jeevak Sopanrao Kapure, Benjamin P. Ross, Irina Vetter, Mark Ashton, Bradley S. Launikonis, William A. Denny, Mohamed Trebak, Gregory R. Monteith
Abstract
influx but avoid the cytotoxicity associated with sustained Orai1 activation. IA65 and/or future analogues with similar Orai1 and CDI activating properties could be fine tuners of physiological processes important in specific disease states, such as cellular migration and immune cell function.
Topics & Concepts
ORAI1Cell biologySTIM1Endoplasmic reticulumEnhancerBiologyChemistryBiochemistryTranscription factorGeneIon Channels and ReceptorsNeurobiology and Insect Physiology ResearchPhytochemicals and Antioxidant Activities