Cu<sup>II</sup>-mediated stabilisation of DNA duplexes bearing consecutive ethenoadenine lesions and its application to a metal-responsive DNAzyme
Silpa Chandran Rajasree, Yusuke Takezawa, Mitsuhiko Shionoya
Abstract
The Cu II -dependent stabilisation of DNA duplexes bearing consecutive 1, N 6 -ethenoadenine (εA) lesions was investigated and applied to the development of a Cu II -responsive split-DNAzyme.
Topics & Concepts
DeoxyribozymeNucleobaseMetalDNABase pairChemistryDuplex (building)Metal ions in aqueous solutionStereochemistryCombinatorial chemistryCrystallographyBiochemistryOrganic chemistryAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryRNA and protein synthesis mechanisms