Design and synthesis of new bis(1,2,4-triazolo[3,4-<i>b</i>][1,3,4]thiadiazines) and bis((quinoxalin-2-yl)phenoxy)alkanes as anti-breast cancer agents through dual PARP-1 and EGFR targets inhibition
Fatma M. Thabet, Kamal M. Dawood, Eman A. Ragab, Mohamed S. Nafie, Ashraf A. Abbas
Abstract
= 80 nM). These results agreed with the molecular docking studies that highlighted the binding disposition of compound 8i inside the PARP-1 and EGFR protein active sites. Hence, compound 8i may serve as a potential anti-breast cancer agent.
Topics & Concepts
CytotoxicityChemistryCytotoxic T cellStereochemistryCombinatorial chemistryMedicinal chemistryBiochemistryIn vitroSynthesis and Biological EvaluationSynthesis and biological activityClick Chemistry and Applications