A Reactive Oxygen Species (ROS) Activated Hydrogen Sulfide (H<sub>2</sub>S) Donor with Self-Reporting Fluorescence
Ning Zhang, Ping Hu, Yanfang Wang, Qing Tang, Qiang Zheng, Zhanlong Wang, Yun He
Abstract
Hydrogen sulfide (H2S) is an important cellular signaling molecule, and its physiological and pathophysiological properties have been under intensive investigation. In this study, a novel ratiometric fluorescent H2S donor (HSD-B) has been developed, which exhibited the following advantages: (i) scavenging ROS and producing H2S simultaneously; (ii) providing ratiometric fluorescence for visualization and quantification of H2S releasing; and (iii) targeting mitochondrion specifically. Moreover, it demonstrated protective effects on myocardial ischemia reperfusion injury in a cellular model. These attractive features promise this HSD-B as a fluorescent H2S donor for future research studies.