Aerobic exercise training reduces cardiac function and coronary flow-induced vasodilation in mice lacking adiponectin
Jacob T. Caldwell, Karissa M. Dieseldorff Jones, Hye‐Rim Park, José R. Pinto, Payal Ghosh, Emily Reid‐Foley, Brody Ulrich, Michael D. Delp, Bradley J. Behnke, Judy M. Muller‐Delp
Abstract
We report that compensatory mechanisms contribute to the maintenance of cardiac and coronary microvascular function in sedentary mice in which adiponectin has been deleted; however, when mice lacking adiponectin are subjected to the physiological stress of exercise training, beneficial coronary microvascular and cardiac adaptations are compromised or absent.
Topics & Concepts
AdiponectinCardiac function curveInternal medicineMedicineAerobic exerciseCardiologyVasodilationEndocrinologyCoronary circulationBlood flowHeart failureObesityInsulin resistanceAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity