Upregulation of ribosome biogenesis via canonical E-boxes is required for Myc-driven proliferation
Norman Zielke, Anna Vähärautio, Jianping Liu, Teemu Kivioja, Jussi Taipale
Abstract
flies are healthy and display only a minor developmental delay, suggesting that it may be possible to treat or prevent tumorigenesis by targeting individual downstream targets of Myc.
Topics & Concepts
BiologyRibosome biogenesisGeneTranscription factorProto-Oncogene Proteins c-mycCarcinogenesisMutantGeneticsPhenotypeGenetic screenDownregulation and upregulationPromoterCell biologyCell growthGene expressionRibosomeRNAGenomics and Chromatin DynamicsRNA and protein synthesis mechanismsCRISPR and Genetic Engineering