Improvement of the Solubility and Evaluation of the Physical Properties of an Inclusion Complex Formed by a New Ferulic Acid Derivative and γ-Cyclodextrin
Nao Ikeda, Yutaka Inoue, Yuka Ogata, Isamu Murata, Xuan Meiyan, Jun Takayama, Takeshi Sakamoto, Mari Okazaki, Ikuo Kanamoto
Abstract
O) revealed cross peaks for protons of the methyl group of FAD012 and a proton (H-3) in the cavity of γCD, so FAD012 presumably interacts with the wide opening of the γCD torus. A solubility test (25 °C) indicated that solubility improved about 5-fold for the 3DGM in comparison to the solubility of FAD012 alone (about 140 μg/mL). Based on these findings, an FAD012/γCD complex was formed by cogrinding, and its solubility improved. These observations are expected to expand the usefulness of cogrinding of FAD012 with γCD using a 3D ball mill.
Topics & Concepts
SolubilityChemistryEndothermic processFerulic acidDerivative (finance)CyclodextrinPowder diffractionProton NMRCrystallographyNuclear chemistryAnalytical Chemistry (journal)StereochemistryOrganic chemistryChromatographyFinancial economicsAdsorptionEconomicsDrug Solubulity and Delivery SystemsCrystallization and Solubility StudiesAnalytical Chemistry and Chromatography