Integrated Transcriptome and Network Analysis Reveals Spatiotemporal Dynamics of Calvarial Suturogenesis
Greg Holmes, Ana S. Gonzalez‐Reiche, Na Lü, Xianxiao Zhou, Joshua Rivera, Divya Kriti, Robert Sebra, Anthony A. Williams, Michael Donovan, S. Steven Potter, Dalila Pinto, Bin Zhang, Harm van Bakel, Ethylin Wang Jabs
Abstract
, demonstrate distinct transcriptional changes involving angiogenesis and ribogenesis, respectively. Co-expression network analysis reveals gene expression modules from which we validate key driver genes regulating osteoblast differentiation. Our study provides a global approach to gain insights into suturogenesis.
Topics & Concepts
MesenchymeBiologyTranscriptomeOsteoblastCalvariaCell biologyCraniofacialGene expressionExtracellular matrixRNAAlternative splicingGene regulatory networkGeneGeneticsMessenger RNAMesenchymal stem cellIn vitroCraniofacial Disorders and Treatmentsdental development and anomaliesCleft Lip and Palate Research