Mechanical Regulation of Mitochondrial Dynamics and Function in a 3D-Engineered Liver Tumor Microenvironment
Adam Frtús, Barbora Smolková, Mariia Uzhytchak, Mariia Lunová, M Jirsa, Yuriy Petrenko, A. Dejneka, Oleg Lunov
Abstract
oxidase I, and slow proliferation rate in comparison with stiff monolayer cultures. Our data reveal the coupling of liver tumor glycolysis to mechanical cues. It is proposed here that soft 3D collagen scaffolds can serve as a useful model for future studies of mechanically regulated cellular functions of various liver (potentially other tissues as well) tumor cells.
Topics & Concepts
Tumor microenvironmentCell biologyDownregulation and upregulationMitochondrionGlycolysisChemistryBiologyCancer researchMetabolismBiochemistryTumor cellsGeneCellular Mechanics and Interactions3D Printing in Biomedical ResearchSpaceflight effects on biology