Exosomal miR-590-3p derived from cancer-associated fibroblasts confers radioresistance in colorectal cancer
Xijuan Chen, Yingqiang Liu, Qinglan Zhang, Baoxing Liu, Yan Cheng, Yonglei Zhang, Yanan Sun, Junqi Liu
Abstract
experimental results confirmed that CAF-derived exosomal miR-590-3p stimulated tumor growth in mice following radiotherapy. Our results demonstrate that miR-590-3p delivery via exosomes derived from CAFs enhances radioresistance in CRC through the positive regulation of the CLCA4-dependent PI3K/Akt signaling pathway.
Topics & Concepts
RadioresistanceColorectal cancerCancer researchCancermicroRNABiologyMedicineOncologyInternal medicineGeneticsRadiation therapyGeneExtracellular vesicles in diseaseCircular RNAs in diseasesMicroRNA in disease regulation