Cationic poly(amino acid) surface functionalized manganese nanoparticles for nitric oxide-based immunotherapy and magnetic resonance imaging
Jong-Woo Lim, Hye Young Son, Yong‐Min Huh, Seungjoo Haam
Abstract
weighted magnetic resonance imaging. Particularly, our results illustrate the therapeutic effects, such as growth inhibition and apoptosis of tumor cells, of hpMNP treated macrophages. Therefore, the newly designed multifunctional PLR-assisted MNPs may facilitate the polarization of M2 macrophages into the M1 phenotype, which can mediate NO-dependent anticancer immunotherapy.
Topics & Concepts
Nitric oxideHyaluronic acidCationic polymerizationMaterials scienceNanoparticleManganese oxideNitric acidApoptosisArginineImmunotherapyBiophysicsChemistryPolymer chemistryNanotechnologyManganeseImmune systemBiochemistryAmino acidMedicineOrganic chemistryImmunologyBiologyAnatomyMetallurgyNanoplatforms for cancer theranosticsImmune cells in cancerNanoparticle-Based Drug Delivery