Obesity modulates cell-cell interactions during ovarian folliculogenesis
Xin Long, Qiuyun Yang, Jingjing Qian, Huiying Yao, Rui Yan, Xin Cheng, Qiancheng Zhang, Chan Gu, Fei Gao, Hongmei Wang, Lin Zhang, Fan Guo
Abstract
highly expressed granulosa cells (GCs) among all the GC subpopulations in obese mice. Under obese conditions, excessive androgen secreted from endocrine theca cells (ETCs) may contribute to the imbalanced change of GC subtypes through ETCs-GCs interactions. This is alleviated by enzalutamide, an androgen receptor antagonist. We also identified and confirmed typical GC markers, such as Marcks and Prkar2b, for sensitive evaluation of female fertility in obesity. These data represent a resource for studying transcriptional networks and cell-cell interactions during folliculogenesis under physiological and pathological conditions.