The interaction between obesity and visceral hypersensitivity
Yanping Wu, Xuefen Gao, Yizun Cheng, Mi Liu, Siyu Liao, Jing Zhou, Jiaming Hao, Gemeng Jiang, Yixuan Lu, Tianyao Qu, Bin Qin, Yan Cheng
Abstract
Obesity has been a worldwide problem associated with numerous chronic diseases such as cardiovascular disease, type 2 diabetes, and metabolic disorders. It may also play a role in visceral hypersensitivity, contributing to irritable bowel syndrome. (i) Adipose tissue secretes various inflammatory mediators, causing intestinal hyperpermeability and nerve endings activation. (ii) Obesity and gastrointestinal microbiota could affect each other, and microbial metabolites can increase sensitivity of the colon. (iii) Vitamin D deficiency contributes to both fat accumulation and disruption of the intestinal mucosal barrier. (iv) Brain-gut axis may be another bridge from obesity to visceral hypersensitivity.