Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs
Shawn Herring, Jessica M. Oda, Jessica Wagoner, Delaney Kirchmeier, Aidan O’Connor, Elizabeth A. Nelson, Qinfeng Huang, Yuying Liang, Lisa Evans DeWald, Lisa M. Johansen, Pamela J. Glass, Gene G. Olinger, Aleksandr Ianevski, Tero Aittokallio, Mary F. Paine, Susan L. Fink, Judith M. White, Stephen J. Polyak
Abstract
Neglected diseases caused by arenaviruses such as Lassa virus (LASV) and filoviruses like Ebola virus (EBOV) primarily afflict resource-limited countries, where antiviral drug development is often minimal. Previous studies have shown that many approved drugs developed for other clinical indications inhibit EBOV and LASV and that combinations of these drugs provide synergistic suppression of EBOV, often by blocking discrete steps in virus entry.