Lung imaging patterns in connective tissue disease–associated interstitial lung disease impact prognosis and immunosuppression response
Boyang Zheng, Daniel-Costin Marinescu, Cameron Hague, Néstor L. Müller, Darra Murphy, Andrew Churg, Joanne L Wright, A. Al-Arnawoot, Ana-Maria Bilawich, Patrick Bourgouin, Gerard Cox, C. Durand, T. Elliot, Jennifer D. Ellis, Jolene H. Fisher, D. Fladeland, Amanda Grant-Orser, G.C. Goobie, Z. Guenther, Ehsan Haider, Nathan Hambly, James Huynh, Kerri A. Johannson, Geoffrey Karjala, Nasreen Khalil, Martin Kolb, Jonathon Leipsic, S.D. Lok, S. Macisaac, Micheal McInnis, H. Manganas, Veronica Marcoux, John R. Mayo, Julie Morisset, Ciaran Scallan, T. Sedlic, Shane Shapera, Kelly Sun, V. Tan, Alyson W. Wong, Christopher J. Ryerson
Abstract
OBJECTIVES: Interstitial lung disease (ILD) in CTDs has highly variable morphology. We aimed to identify imaging features and their impact on ILD progression, mortality, and immunosuppression response. METHODS: Patients with CTD-ILD had high-resolution chest CT (HRCT) reviewed by expert radiologists blinded to clinical data for overall imaging pattern [usual interstitial pneumonia (UIP); non-specific interstitial pneumonia (NSIP); organizing pneumonia (OP); fibrotic hypersensitivity pneumonitis (fHP); and other]. Transplant-free survival and change in percent-predicted forced vital capacity (FVC) were compared using Cox and linear mixed-effects models adjusted for age, sex, smoking, and baseline FVC. FVC decline after immunosuppression was compared with pre-treatment. RESULTS: Among 645 CTD-ILD patients, the most frequent CTDs were SSc (n = 215), RA (n = 127), and inflammatory myopathies (n = 100). NSIP was the most common pattern (54%), followed by UIP (20%), fHP (9%), and OP (5%). Compared with the case for patients with UIP, FVC decline was slower in patients with NSIP (by 1.1%/year, 95% CI 0.2, 1.9) or OP (by 3.5%/year, 95% CI 2.0, 4.9), and mortality was lower in patients with NSIP [hazard ratio (HR) 0.65, 95% CI 0.45, 0.93] or OP (HR 0.18, 95% CI 0.05, 0.57), but higher in fHP (HR 1.58, 95% CI 1.01, 2.40). The extent of fibrosis also predicted FVC decline and mortality. After immunosuppression, FVC decline was slower compared with pre-treatment in NSIP (by 2.1%/year, 95% CI 1.4, 2.8), with no change for UIP or fHP. CONCLUSION: Multiple radiologic patterns are possible in CTD-ILD, including a fHP pattern. NSIP and OP were associated with better outcomes and response to immunosuppression, while fHP had worse survival compared with UIP.