Myeloid-specific blockade of Notch signaling ameliorates nonalcoholic fatty liver disease in mice
Jian Ding, Ming Xu, Wei Du, Zhiqiang Fang, Hao Xu, Jingjing Liu, Ping Song, Xu Chen, Zhiwen Li, Zhen‐Sheng Yue, Yu‐Wei Ling, Juanli Duan, Kaishan Tao, Fei He, Lin Wang
Abstract
Combined, macrophage RBP-J promotes the progression of NAFLD at least partially through regulating the expression of pro-inflammatory cytokines IL1β and TNFα. Infusion of exosomes loaded with RBP-J decoy ODNs might be a promising therapy to treat NAFLD.
Topics & Concepts
Sirius RedNonalcoholic fatty liver diseaseNotch signaling pathwayBiologyFatty liverSteatohepatitisWestern blotSteatosisSignal transductionMolecular biologyPathologyImmunohistochemistryEndocrinologyImmunologyCell biologyMedicineBiochemistryGeneDiseaseMicroRNA in disease regulationLiver Disease Diagnosis and TreatmentCircular RNAs in diseases