Epigenetic age acceleration in idiopathic pulmonary fibrosis revealed by DNA methylation clocks
Daniel Kurbanov, Farida Ahangari, Taylor Adams, Ruben De Man, Jessica Tang, Marianne Carlon, Nebal Abu Hussein, Emmanuela Cortesi, Marta Zapata, Laurens De Sadeleer, Wim Wuyts, Bart Vanaudenaerde, Naftali Kaminski, John E. McDonough
2025American Journal of Physiology-Lung Cellular and Molecular Physiology10 citationsDOIOpen Access PDF
Abstract
Using epigenetic clocks, we found a notable acceleration of biological aging in IPF tissues, particularly in DunedinPACE, suggesting that the biological aging process in IPF is accelerated and closely related to the severity of the disease. The study also underscores DNA methylation's potential as a biomarker for IPF, as well as the dynamics of epigenetic aging and the need to consider biological age in medical research and healthcare.
Topics & Concepts
EpigeneticsDNA methylationContext (archaeology)BiomarkerBiological ageIdiopathic pulmonary fibrosisDiseaseMedicineBioinformaticsBiologyPulmonary fibrosisLungFibrosisPathologyInternal medicineGeneticsGerontologyGeneGene expressionPaleontologyInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis