C–C Bond Cleavage-Induced C- to N-Acyl Transfer for Synthesis of Amides
Su Eun Lee, Youngsoo Kim, Yong Ho Lee, Y. H. Shin
Abstract
A new approach for the preparation of amides was developed using C-C bond cleavage that initiates C- to N-acyl transfer, employing activated ketones as acylation reagents and amine nucleophiles. The reaction was operational under the coupling reagent system that is commonly utilized for peptide bond formations. The method enables practical preparation of amides using linear and cyclic ketone substrates under mild conditions.
Topics & Concepts
ChemistryReagentAcylationPeptide bondCleavage (geology)NucleophileBond cleavageKetoneAmine gas treatingCombinatorial chemistryOrganic chemistryStereochemistryCatalysisEngineeringEnzymeFracture (geology)Geotechnical engineeringChemical Synthesis and AnalysisAdvanced Synthetic Organic ChemistryAsymmetric Synthesis and Catalysis