Design, synthesis and biological evaluation of peptidomimetic benzothiazolyl ketones as 3CLpro inhibitors against SARS-CoV-2
Hanxi Yang, Mengyuan You, Xiaoyang Shu, Jingyao Zhen, Mengwei Zhu, Tiantian Fu, Yan Zhang, Yan Zhang, Xiangrui Jiang, Leike Zhang, Yechun Xu, Yumin Zhang, Yumin Zhang, Haixia Su, Qiumeng Zhang, Jingshan Shen
Topics & Concepts
ChemistryPharmacokineticsIC50PotencyPharmacologyEnzymePeptidomimeticStereochemistryStructure–activity relationshipCytotoxicityMicrosomeKetoneIn vitroBiochemistryOrganic chemistryPeptideMedicineComputational Drug Discovery MethodsSARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approaches