Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma
Deepak Bararia, Johannes Adrian Hildebrand, Sebastian Stolz, Sarah Haebe, Stefan Alig, Christopher Trevisani, Francisco Osorio‐Barrios, Michael D. Bartoschek, Michael Mentz, Alessandro Pastore, Erik Gaitzsch, Michael Heide, Vindi Jurinović, Katharina Rautter, Jay Gunawardana, Muhammed B. Sabdia, Monika Szczepanowski, Julia Richter, Wolfgang Hiddemann, Abner Louissaint, Christina Ludwig, Sebastian Bultmann, Heinrich Leonhardt, Sebastian Eustermann, Karl‐Peter Hopfner, Wolfgang Hiddemann, Michael von Bergwelt‐Baildon, Christian Steidl, Robert Kridel, Joshua W.D. Tobin, Maher K. Gandhi, David M. Weinstock, Marc Schmidt‐Supprian, Menyhárt B. Sárosi, Martina Rudelius, Verena Passerini, Josef Mautner, Oliver Weigert
Abstract
T cell infiltration and proinflammatory cytokine perturbation in a mouse model and in human FLs. In mice, this CTSS-induced immune microenvironment promoted tumor growth. Clinically, patients with CTSS-hyperactive FL had better treatment outcomes with standard immunochemotherapies, indicating that these immunosuppressive regimens target both the lymphoma cells and the tumor-promoting immune microenvironment.