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Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines

Xuan Zhang, Yonghan He, Peiyi Zhang, Vivekananda Budamagunta, Dongwen Lv, Dinesh Thummuri, Yang Yang, Jing Pei, Yaxia Yuan, Daohong Zhou, Guangrong Zheng

2020European Journal of Medicinal Chemistry64 citationsDOIOpen Access PDF

Topics & Concepts

Ubiquitin ligaseChemistryUbiquitinCell cultureDNA ligaseCereblonCancer researchBiologyBiochemistryGeneticsDNAGeneProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsPeptidase Inhibition and Analysis
Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines | Litcius