Three component hydroxyletherification and hydroxylazidation of (trifluoromethyl)alkenes: access to α-trifluoromethyl β-heteroatom substituted tertiary alcohols
Hao Zeng, Chuanle Zhu, Chi Liu, Yingying Cai, Fulin Chen, Huanfeng Jiang
Abstract
The three component hydroxyletherification and hydroxylazidation reactions of (trifluoromethyl)alkenes are reported, providing various useful α-trifluoromethyl β-heteroatom substituted tertiary alcohols in high yields. The ipso-defluorooxylation of (trifluoromethyl)alkenes with oximes is completely inhibited. A pesticidal active compound could be synthesized with our method.
Topics & Concepts
TrifluoromethylHeteroatomChemistryComponent (thermodynamics)Tertiary alcoholsOrganic chemistryMedicinal chemistryAlcoholRing (chemistry)AlkylPhysicsThermodynamicsFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsCyclopropane Reaction Mechanisms