In situ engineering of mRNA-CAR T cells using spleen-targeted ionizable lipid nanoparticles to eliminate cancer cells
Yuan Li, Yishi Tian, Chanjuan Li, Wenli Fang, Xiaohong Li, Zhangyan Jing, Zhaoxin Yang, Xiaozhou Zhang, Xiaozhou Zhang, Yanlan Huang, Jiaqi Gong, Fanqiang Meng, Lin Qi, Liang Xin, Linlin Hou, Kai Lv, Xudong Zhang, Xudong Zhang
Topics & Concepts
SpleenIn situMessenger RNANanoparticleCancerCancer cellNanotechnologyChemistryCancer researchMaterials scienceBiologyBiochemistryImmunologyGeneGeneticsOrganic chemistryCAR-T cell therapy researchViral Infectious Diseases and Gene Expression in InsectsRNA Interference and Gene Delivery