Electrochemical Oxidative Coupling Between Benzylic C(sp<sup>3</sup>)–H and N–H of Secondary Amines: Rapid Synthesis of α-Amino α-Aryl Esters
Yadav Kacharu Nagare, Imtiyaz Ahmad Shah, Jyothi Yadav, Amol Prakash Pawar, Rahul Choudhary, Pankaj Chauhan, Indresh Kumar
Abstract
)-H bond and various secondary amines is reported. The electronic behavior of two electronically rich units viz the α-position of α-aryl acetates and amines was engineered electrochemically, thus facilitating their reactivity for the direct access of α-amino esters. A series of acyclic/cyclic secondary amines and α-aryl acetates were tested to furnish the corresponding α-amino esters with high yields (up to 92%) under mild conditions.
Topics & Concepts
ChemistryElectrochemistryArylIntermolecular forceReactivity (psychology)Oxidative coupling of methaneChemical synthesisMedicinal chemistryOxidative phosphorylationAmine gas treatingOrganic chemistryMoleculeCombinatorial chemistryStereochemistryIn vitroCatalysisElectrodeAlkylBiochemistryPathologyMedicineAlternative medicinePhysical chemistryCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques