Cerebral hemodynamics and capillary dysfunction in late-onset major depressive disorder
Rikke Beese Dalby, Simon Fristed Eskildsen, Poul Videbech, Raben Rosenberg, Leif Østergaard
Abstract
) but preserved capillary function in the subthalamic nucleus and globus pallidus bilaterally, and hyperactivity with preserved capillary function (increased nCBF) in the cerebellum and brainstem. Our data support that perfusion changes in deep nuclei and cerebellum reflect abnormally low and high activity, respectively, in MDD patients, but suggest that microvascular pathology affects neurovascular coupling in ventral circuits. We speculate that microvascular pathology is important for our understanding of etiology of late-onset MDD as well as infererences about resulting brain activity changes.
Topics & Concepts
Cerebral blood flowAnterior cingulate cortexCardiologyMajor depressive disorderInternal medicinePsychologyBrainstemGlobus pallidusNeuroscienceMedicineCentral nervous systemBasal gangliaCognitionAdvanced MRI Techniques and ApplicationsFunctional Brain Connectivity StudiesAdvanced Neuroimaging Techniques and Applications