<sup>64</sup> Cu-ATSM Positron Emission Tomography/Magnetic Resonance Imaging of Hypoxia in Human Atherosclerosis
Xingyu Nie, Andrew Elvington, Richard Laforest, Jie Zheng, Thomas Voller, Mohamed A. Zayed, Dana R. Abendschein, Nilantha Bandara, Jinbin Xu, Ran Li, Gwendalyn J. Randolph, Robert J. Gropler, Suzanne E. Lapi, Pamela K. Woodard
Abstract
he macrophage-rich core of advanced human atheroma has been shown to be hypoxic, which may have implications for plaque stability. Recently, we showed that the hypoxia positron emission tomography (PET) imaging agent 64 Cu-diacetyl-bis(N4-methylthiosemicarbazone) ( 64 Cu-ATSM) could be used for visualizing hypoxic cells in atherosclerosis in animal models. In this study, we investigated the feasibility of 64 Cu-ATSM Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) for detecting hypoxic cells in human atherosclerotic plaque.