APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer’s pathology in trisomy 21 neurons
Chun-I Wu, Elizabeth A. Vinton, Richard V. Pearse, Keunjung Heo, Aimee J. Aylward, Yi‐Chen Hsieh, Yan Bi, Sopefoluwa Adeleye, Seeley B. Fancher, Duc M. Duong, Nicholas T. Seyfried, Thomas L. Schwarz, Tracy L. Young‐Pearse
Topics & Concepts
BiologyNeuroscienceDYRK1ASynaptic vesicle recyclingPhenotypeSynaptic vesicleAlzheimer's diseaseProteomicsCell biologyPhosphorylationGeneGeneticsDiseasePathologyMedicineVesicleMembraneDown syndrome and intellectual disability researchAlzheimer's disease research and treatments