Glycolaldehyde as a Bio‐Based C<sub>1</sub> Building Block for Selective <i>N</i>‐Formylation of Secondary Amines
Matthew T. Flynn, Xin Liu, A. Dell’Acqua, Jabor Rabeah, Angelika Brückner, Eszter Mikó–Baráth, Sergey Tin, Johannes G. de Vries
Abstract
Biomass derived glycolaldehyde was employed as C1 building block for the N-formylation of secondary amines using air as oxidant. The reaction is atom economic, highly selective and proceeds under catalyst free conditions. This strategy can be used for the synthesis of cyclic and acyclic formylamines, including DMF. Mechanistic studies suggest a radical oxidation pathway.
Topics & Concepts
FormylationGlycolaldehydeChemistryCatalysisBlock (permutation group theory)Combinatorial chemistryOrganic chemistryMathematicsGeometryCarbon dioxide utilization in catalysisCatalysis for Biomass ConversionAsymmetric Hydrogenation and Catalysis