Ptxplatin: a multifunctional Pt(<scp>iv</scp>) antitumor prodrug
Ran Zhang, Yueyue Zhang, Liumei Tang, Yixing Xu, Hao Li, Xueping Jiang, Xiangdong Xin, Zhongzheng Gui
Abstract
Ptxplatin, comprising paclitaxel and cisplatin, intervened in several cellular processes including the p53 apoptosis pathway, mitochondrial damage and ER stress to kill cancer cells.
Topics & Concepts
PaclitaxelProdrugCisplatinApoptosisChemistryCancer researchPharmacologyCancerCell biologyBiochemistryChemotherapyBiologyMedicineInternal medicineMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsClick Chemistry and Applications