Interleukin-2–based therapies in cancer
Miro E. Raeber, Dilara Şahin, Onur Boyman
Abstract
Molecular insights into the mechanism of beneficial and adverse effects of interleukin-2 (IL-2) have resulted in the development of improved IL-2 formulations with IL-2 receptor bias and tissue-targeting properties. Several of these compounds are currently in clinical development and are ushering IL-2 therapy into the current era of cancer immunotherapy.
Topics & Concepts
Cancer immunotherapyMedicineImmunotherapyCancerMechanism (biology)Adverse effectInterleukinCancer researchCancer therapyImmunologyBioinformaticsPharmacologyCytokineBiologyInternal medicineEpistemologyPhilosophyNeuroblastoma Research and TreatmentsImmune Cell Function and InteractionVirus-based gene therapy research