Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice
Danyang Li, Mi‐Hua Liu, Zhe Li, Zheng Guo, Amei Chen, Lei Zhao, Ping Yang, Wei Li, Yaxi Chen, Xiong Z. Ruan
Abstract
, we also found that sterol-resistant SCAP overexpression in VSMCs increased the release of inflammatory cytokines and induced endothelial cell injury when both cell types were cocultured. Furthermore, we demonstrated that sterol-resistant SCAP overexpression in VSMCs promoted SCAP and NLRP3 inflammasome cotranslocation to the Golgi and increased the activation of the NLRP3 inflammasome pathway. These findings suggested that sterol-resistant SCAP in VSMCs of mice induced vascular inflammation and endothelial dysfunction, consequently accelerating atherosclerosis by activating the NLRP3 inflammasome pathway.
Topics & Concepts
InflammasomeInflammationVascular smooth muscleMedicinePharmacologyImmunologySmooth muscleInternal medicineCholesterol and Lipid MetabolismAtherosclerosis and Cardiovascular DiseasesInflammasome and immune disorders