Kruppel-like factor 2 contributes to blood-spinal cord barrier integrity and functional recovery from spinal cord injury by augmenting autophagic flux
Zili He, Jiqing Du, Yu Zhang, Yitie Xu, Qian Huang, Qingwei Zhou, Min Wu, Yao Li, Xie Zhang, Hongyu Zhang, Yuepiao Cai, Keyong Ye, Xiangyang Wang, Yingze Zhang, Qi Han, Jian Xiao
Abstract
Endothelial KLF2 as one of the key contributors to SCI-mediated ALP dysfunction and BSCB disruption. KLF2 could be a promising pharmacological target for the management and treatment of SCI.
Topics & Concepts
KLF2AutophagySpinal cord injuryExtravasationEndothelial dysfunctionCell biologyBlood–brain barrierWestern blotEvans BlueSpinal cordChemistryMedicineBiologyImmunologyNeuroscienceInternal medicineDownregulation and upregulationCentral nervous systemBiochemistryGeneApoptosisKruppel-like factors researchLipid metabolism and disordersPeroxisome Proliferator-Activated Receptors