Selection of CD133-targeted DNA aptamers for the efficient and specific therapy of colorectal cancer
Wenjing Li, Wang Zheng, Tian Gao, Shengkai Sun, Mingsheng Xu, Renjun Pei
Abstract
results demonstrated the highly efficient therapy and low toxicity of the chimera. Given the overexpression of CD133 in various tumors, our work provides a promising tool for specific cell identification and a wide range of applications in the field of targeted cancer therapy.
Topics & Concepts
AptamerChimera (genetics)Colorectal cancerIn vivoCancer researchTargeted therapySystematic evolution of ligands by exponential enrichmentDoxorubicinTargeted drug deliveryCancer cellCancerComputational biologyMedicineChemistryNanotechnologyBiologyDrug deliveryMaterials scienceChemotherapyMolecular biologyBiotechnologyRNAInternal medicineBiochemistryGeneAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryNanopore and Nanochannel Transport Studies