One‐pot multicomponent designing of novel 2‐imino‐4‐arylidene‐1,3‐thiazolidin‐4‐one
Amer A. Amer, Antar A. Abdelhamid, Amany Sh. Elnakeeb, H. Salah
Abstract
Abstract An unprecedented series of 2‐imino‐1,3‐thiazolidin‐4‐ones were designed by straightforward and dynamic technique via one‐pot three‐component reaction of isothiocyanatobenzene, primary amines, ethyl bromoacetate and/or phenacylbromide. Furthermore, we found that the reaction between 2‐imino‐1,3‐thiazolidin‐4‐one and arylidenemalononitrile using of C 2 H 5 ONa as catalyst gave the corresponding 3‐(2‐phenylethyl)‐5‐(4‐arylidene)‐2‐(phenyl imino)‐1,3‐thia‐zolidin‐4‐one instead of 5‐amino‐7‐aryl‐3‐(2‐phenylethyl)‐2‐(phenylimino)‐3,7‐dihydro‐2 H ‐6‐carbonitrile. The identical molecules were designed through other routes via the reaction of 2‐imino‐1,3‐thiazolidin‐4‐one with the corresponding aryl carbaldehyde.