Novel cytotoxic 1,10-phenanthroline–triterpenoid amphiphiles with supramolecular characteristics capable of coordinating <sup>64</sup>Cu(<scp>ii</scp>) labels
Uladzimir Bildziukevich, Zülal Özdemir, David Šaman, Martin Vlk, Miroslav Šlouf, Lucie Rárová, Zdeněk Wimmer
Abstract
Novel 1,10-phenanthroline–triterpenoid amphiphiles formed nano-assemblies in water, coordinated Cu( ii ) and 64 Cu( ii ) salts for potential cancer monitoring and therapy, and displayed cytotoxicity partly dependent on the formation of nano-assemblies.
Topics & Concepts
ChemistryAmphiphilePhenanthrolineMoleculeSpermineSupramolecular chemistryStereochemistryCombinatorial chemistryBetulinic acidOleanolic acidCytotoxicityCrystallographyOrganic chemistryBiochemistryGeneticsIn vitroCopolymerBiologyEnzymeMedicinePathologyPolymerAlternative medicineRadiopharmaceutical Chemistry and ApplicationsPeptidase Inhibition and AnalysisChemical Synthesis and Analysis