Acquired thrombotic thrombocytopenic purpura with possible association with AstraZeneca‐Oxford COVID‐19 vaccine
Mona Al‐Ahmad, Mona Al‐Rasheed, Neveen Shalaby
Abstract
Acquired thrombotic thrombocytopenic purpura is characterized by the microvascular aggregation of platelets and microangiopathic hemolytic anemia causing ischemia of multiple organs including the brain mainly and less likely the kidney and the heart. The disease is caused by severe reduction in the activity of ADAMTS 13 due to presence of inhibitory antibodies.
Topics & Concepts
Thrombotic thrombocytopenic purpuraMicroangiopathic hemolytic anemiaMedicinePlateletCoronavirus disease 2019 (COVID-19)ImmunologyAntibodyHemolytic anemiaSchistocyteVirologyDiseaseInternal medicineInfectious disease (medical specialty)Complement system in diseasesSARS-CoV-2 and COVID-19 ResearchBlood groups and transfusion