SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients
Daryl Geers, Marc C. Shamier, Susanne Bogers, Gerco den Hartog, Lennert Gommers, Nella N. Nieuwkoop, Katharina S. Schmitz, Laurine C. Rijsbergen, Jolieke A. T. van Osch, Emma Dijkhuizen, Gaby Smits, Anouskha D. Comvalius, Djenolan van Mourik, Tom G. Caniels, Marit J. van Gils, Rogier W. Sanders, Bas B. Oude Munnink, Richard Molenkamp, Herbert de Jager, Bart L. Haagmans, Rik L. de Swart, Marion Koopmans, Robert S. van Binnendijk, Rory D. de Vries, Corine H. GeurtsvanKessel
Abstract
Infection- or vaccination-induced SARS-CoV-2 S–specific CD4 + T cells are indifferent to the S mutations of variants of concern.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)VirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VaccinationImmunologyImmune escape2019-20 coronavirus outbreakBiologyConvalescent plasmaImmune systemMedicineDiseaseOutbreakInfectious disease (medical specialty)PathologySARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-19