Design and synthesis of novel 1,3,4‐oxadiazole based azaspirocycles catalyzed by <scp>NaI</scp> under mild condition and evaluated their antidiabetic and antibacterial activities
Ashish radia, Jaydeep Lalpara, Ishita Modasiya, G. G. Dubal
Abstract
Abstract A modest, efficient, and mild synthetic procedure has been developed for the synthesis of novel series of 1,3,4‐oxadiazole containing azaspirocycles derivatives. The reaction of 1,3,4‐oxadiazole derivative with diverse azaspiro compounds under room temperature condition with helps of sodium iodide catalyst and polar aprotic solvent. Numerous compensations of this strategy embrace less time required, yield increment, consumption of all reactants, and mild condition. All synthesized compounds evaluated for in vitro antidiabetic and antibacterial screening. Among them some compounds show significant biological response.
Topics & Concepts
ChemistryYield (engineering)OxadiazoleCatalysisCombinatorial chemistrySolventDerivative (finance)Antibacterial activityOrganic chemistryBacteriaGeneticsEconomicsFinancial economicsBiologyMetallurgyMaterials scienceSynthesis and Biological EvaluationSynthesis and biological activityMulticomponent Synthesis of Heterocycles