Inhibition of Antiviral Innate Immunity by Foot-and-Mouth Disease Virus L <sup>pro</sup> through Interaction with the N-Terminal Domain of Swine RNase L
Chao Sui, Dandan Jiang, Xiangju Wu, Sidang Liu, Feng Li, Li Pan, Xiaoyan Cong, Juntong Li, Dongwan Yoo, Daniel L. Rock, Laura C. Miller, Changhee Lee, Yijun Du, Jing Qi
Abstract
inhibits apoptosis through interacting with sRNase L. This study demonstrates a novel mechanism by which FMDV has evolved to inhibit host innate immune responses.
Topics & Concepts
BiologyFoot-and-mouth disease virusInnate immune systemVirologyInterferonPicornavirusRNase PVirusProtein kinase RAphthovirusViral replicationImmune systemCell biologyRNAImmunologySignal transductionGeneticsMitogen-activated protein kinase kinaseGeneProtein kinase CAnimal Disease Management and EpidemiologyViral Infections and Immunology ResearchVector-Borne Animal Diseases